Chronic overcirculation-induced pulmonary arterial hypertension in aorto-caval shunt

Autor: Elena Nicolato, Elisabetta Milani, Giuseppe Faggian, Beatrice Salvetti, Grazia Ucci, Alessandro Mazzucco, Flavia Merigo, Alessio Rungatscher, Giovanni Battista Luciani, Daniele Linardi
Rok vydání: 2014
Předmět:
Male
medicine.medical_specialty
Heart Ventricles
Hypertension
Pulmonary
ventricular vascular coupling
ventricular interdependence
experimental model
Volume overload
Diastole
Hemodynamics
Blood Pressure
Pulmonary Artery
Vascular Remodeling
Biochemistry
Rats
Sprague-Dawley
pulmonary arterial hypertension
Internal medicine
medicine.artery
medicine
Animals
vascular remodeling
right ventricle overload
volume overload
aorto-caval shunt
rats
pressure-volume loops
Lung
Aorta
business.industry
Stroke Volume
Ultrasonography
Doppler
Cell Biology
medicine.disease
Magnetic Resonance Imaging
Pulmonary hypertension
Rats
Disease Models
Animal
Preload
medicine.anatomical_structure
Echocardiography
Regional Blood Flow
Ventricle
Anesthesia
Pulmonary artery
cardiovascular system
Cardiology
Cardiology and Cardiovascular Medicine
business
Shunt (electrical)
Zdroj: Microvascular Research. 94:73-79
ISSN: 0026-2862
DOI: 10.1016/j.mvr.2014.05.005
Popis: Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathophysiology and the possible determination of pulmonary arterial hypertension of different periods of shunt exposure are still undefined. A method to create standardized, reproducible aorto-caval shunt was developed in growing rats (260±40 g). Three groups of animals were considered: shunt exposure for 10 weeks, shunt exposure for 20 weeks and control (sham laparotomy). Echocardiography and magnetic resonance revealed increased right ventricular end diastolic area in shunt at 10 weeks compared to control. Hemodynamic analysis demonstrated increased right ventricular afterload and increased effective pulmonary arterial elastance (Ea) in shunt at 20 weeks compared to control (1.29±0.20 vs. 0.14±0.06 mmHg/μl, p=0.004). At the same time point, the maximal slope of end-systolic pressure-volume relationship (Ees) decreased (0.5±0.2 mmHg/ml vs. 1.2±0.3, p
Databáze: OpenAIRE
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