Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer
| Autor: | Ming-Je Yang, Jaw-Yuan Wang, Hua-Hsien Chiu, Ming-Sung Chang, Tian-Lu Cheng, Hui-Jen Chang, Fu-Yen Chung, Chung-Chi Chen, Ming-Yii Huang, Shiu-Ru Lin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Male endocrine system medicine.medical_specialty Colorectal cancer Taiwan medicine.disease_cause Asian People Antigens Neoplasm Internal medicine Gene expression medicine Gene family Humans neoplasms Gene Lymph node Oligonucleotide Array Sequence Analysis Melanoma-associated antigen business.industry Gene Expression Profiling General Medicine Middle Aged medicine.disease Neoplasm Proteins Gene expression profiling medicine.anatomical_structure Immunology Surgery Female business Carcinogenesis Colorectal Neoplasms |
| Zdroj: | Journal of surgical oncology. 102(2) |
| ISSN: | 1096-9098 |
| Popis: | Background The melanoma-associated antigen (MAGE) gene family consists of different expression patterns in various tumor types. They are considered tumor-specific antigens and are ideal targets for cancer immunotherapy. The purpose of this study is to identify the expression profiles of the MAGE family genes in Taiwanese colorectal cancer patients. Methods In this study, a well-constructed chip array platform was used to analyze the expression of the MAGE family genes of 100 colorectal cancer tissues. Statistical analysis of the experimental results and patients' clinical manifestations were also conducted. Results The results showed MAGE-A2 (87%), -A7 (83%), -A8 (75%), -A12 (71%), -B2 (75%), -B3 (79%), -D2 (75%), -F1 (79%), and -H1 (70%) were significantly overexpressed genes in colorectal cancer tissues. MAGE-A2 was the most highly overexpressed gene among the MAGE family. MAGE-B3 gene expression is statistically correlated with tumor size, lymph node, and UICC stage. In addition, the overexpression of MAGE-D2 and -H1 genes are statistically correlated to the tumor size and depth, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text