Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome
| Autor: | Fu Zhong, Xia Gao, Weijing Cui, Yue Li, Chengdong Kang, Qing-Ju Liu, Zichuan Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Nephrotic Syndrome Peptide Hormones Blood lipids Hyperlipidemias Urine 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Membranous nephropathy Angiopoietin-Like Protein 8 Internal medicine Hyperlipidemia medicine Humans Creatinine Proteinuria business.industry Research medicine.disease Lipids Diseases of the genitourinary system. Urology Cross-Sectional Studies 030104 developmental biology chemistry Nephrology Case-Control Studies Mesangial proliferative glomerulonephritis Female RC870-923 medicine.symptom business Nephrotic syndrome Biomarkers |
| Zdroj: | BMC Nephrology, Vol 22, Iss 1, Pp 1-7 (2021) BMC Nephrology |
| ISSN: | 1471-2369 |
| Popis: | Background This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria. Methods ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls. Results Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P P P P P P P = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different. Conclusions Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria. |
| Databáze: | OpenAIRE |
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