Sterol and Fatty Acid Composition of Candida lusitaniae Clinical Isolates
| Autor: | A. Favel, J. Coulon, Annie Michel-Nguyen, R. Bonaly, Florence Peyron, R. Calaf |
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| Rok vydání: | 2002 |
| Předmět: |
Antifungal Agents
Isomerase Microbiology chemistry.chemical_compound Mechanisms of Resistance Amphotericin B medicine Humans Pharmacology (medical) Candida Pharmacology chemistry.chemical_classification Ergosterol biology Candida lusitaniae Fatty Acids Fatty acid biology.organism_classification Yeast In vitro Sterol Sterols Infectious Diseases chemistry Biochemistry medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 46:531-533 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | The sterol and fatty acid compositions of four amphotericin B-resistant and of two amphotericin B-susceptible Candida lusitaniae clinical isolates were determined. A flow cytofluorometric susceptibility test (FCST) with a membrane potential-sensitive cationic dye was used as a complement to the conventional method for selecting the isolates. Compared to susceptible isolates, resistant ones showed a greatly reduced ergosterol content and changes in sterol composition, consistent with a defect in Δ8→7 isomerase. Within each group, no correlation between the sterol or fatty acid pattern or composition and both the degree of in vitro susceptibility and FCST MIC was found. |
| Databáze: | OpenAIRE |
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