Frequency, Clinicopathologic Characteristics, and Follow-up of HER2-Positive Nonpleomorphic Invasive Lobular Carcinoma of the Breast
| Autor: | Marcus D’Aguiar, Bradley M. Turner, Shan Gao, Xi Wang, Linda Schiffhauer, Xueya Cai, Rana Ajabnoor, Huina Zhang, Qi Yang, Ioana Moisini, David G. Hicks |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Receptor ErbB-2 medicine.medical_treatment Breast Neoplasms Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans skin and connective tissue diseases Receptor Human Epidermal Growth Factor Receptor 2 Neoadjuvant therapy Aged Neoplasm Staging Aged 80 and over business.industry Hazard ratio General Medicine Middle Aged medicine.disease Prognosis body regions Carcinoma Lobular 030104 developmental biology Receptors Estrogen 030220 oncology & carcinogenesis Invasive lobular carcinoma Population study Female business Receptors Progesterone Hormone Follow-Up Studies |
| Zdroj: | American journal of clinical pathology. 153(5) |
| ISSN: | 1943-7722 |
| Popis: | Objectives To investigate human epidermal growth factor receptor 2 (HER2)-positive nonpleomorphic invasive lobular carcinoma (ILC), which has rarely been addressed. Methods Clinicopathologic characteristics and follow-up of HER2-positive nonpleomorphic ILCs were collected and compared to those of HER2-negative counterparts. Results Twenty-one cases of HER2-positive nonpleomorphic ILCs were identified, 6.3% of the study population. Compared to HER2-negative nonpleomorphic ILC, patients with HER2 positivity were older (P < .05), likely to be hormonal receptor negative (P < .01), and had higher histologic grade and angiolymphatic invasion (P < .01). HER2 positivity in nonpleomorphic ILCs was associated with higher recurrence/metastasis with hazard ratio of 2.03 (P < .05). No patient who received neoadjuvant therapy achieved pathologic complete response, and HER2-targeted therapy tended to reduce recurrence/metastasis in patients with HER2-positive nonpleomorphic ILC. Conclusions Our results highlight the existence of HER2 positivity in nonpleomorphic ILCs and reinforce that HER2 is associated with worse prognosis in nonpleomorphic ILC. |
| Databáze: | OpenAIRE |
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