Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response
| Autor: | Qiankun Xuan, Li-Hua He, Xiao-Qing Chen, Yang-Hong Xi, Jian Guo, Wen-Na Kong, Donghua Wen, Yong-Ming He, Fei Fu, Li-Jun Ni, Aiping Zhou, Wenjuan Wu, Xiaoyu Yu, Yu-Feng Yao |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) hyphal development Hypha vaginal mucosa 030106 microbiology lcsh:QR1-502 medicine.disease_cause Microbiology lcsh:Microbiology 03 medical and health sciences S. agalactiae C. albicans Immunity medicine Lavage fluid Colonization TH17 response Candida albicans Original Research biology Host (biology) biology.organism_classification Corpus albicans 030104 developmental biology Streptococcus agalactiae |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 9 (2018) |
| ISSN: | 1664-302X |
| DOI: | 10.3389/fmicb.2018.00198 |
| Popis: | Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1β, IL-6 and TNF-α showed a increase on co-infection with S. agalactiae, while the level of TH17 T cells and IL-17 in the cervicovaginal lavage fluid were significantly decreased. Our results indicate that S. agalactiae inhibits C. albicans hyphal development by downregulating the expression of EFG1-Hwp1. The interaction between S. agalactiae and C. albicans may attenuate host vaginal mucosal TH17 immunity and contribute to mucosal colonization by C. albicans. |
| Databáze: | OpenAIRE |
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