Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration
| Autor: | Timo Saarela, Outi Aikio, Annamari Salminen, Mikko Hallman, Marita Valkama, Markku Leskinen, Pia Härkin, Antti Härmä |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Inflammation Placebo Gastroenterology C-reactive protein chemistry.chemical_compound Internal medicine health services administration Malondialdehyde medicine Humans Ductus Arteriosus Patent Acetaminophen biology Respiratory distress business.industry digestive oral and skin physiology Infant Newborn Obstetrics and Gynecology Interleukin Very low gestational age Patent Ductus Arteriosus Cytokine chemistry Pediatrics Perinatology and Child Health biology.protein Cytokines Premature Birth Administration Intravenous medicine.symptom Chemokines business Biomarkers Infant Premature medicine.drug |
| Zdroj: | Early human development. 161 |
| ISSN: | 1872-6232 |
| Popis: | Background: Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth. Objective: The aim of this study was to evaluate the association between paracetamol treatment and serum inflammatory biomarkers in very preterm infants with respiratory distress. Study design: The infants were randomly assigned to intravenous paracetamol or placebo during the first 4 days of life, and others received a lower dose of paracetamol unblinded. Serum samples were used for the analysis of 10 cytokines, C-reactive protein (CRP) and malondialdehyde (MDA). The impact of paracetamol on the biomarkers was evaluated, based on the levels during the early ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect