Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

Autor:	M.P. Yeste, C. Fernández-Ponce, E. Félix, M. Tinoco, R. Fernández-Cisnal, C. García-Villar, C. Pfaff, J. Kriwet, E. Natividad, M.A. Cauqui, F. Garcia-Cozar, R. Litrán, O. Bomati-Miguel
Přispěvatelé:	[Yeste, M. P.] Univ Cadiz, Fac Sci, Dept Mat Sci & Met Engn & Inorgan Chem, Cadiz 11510, Spain, [Cauqui, M. A.] Univ Cadiz, Fac Sci, Dept Mat Sci & Met Engn & Inorgan Chem, Cadiz 11510, Spain, [Yeste, M. P.] Univ Cadiz, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, [Felix, E.] Univ Cadiz, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, [Cauqui, M. A.] Univ Cadiz, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, [Litran, R.] Univ Cadiz, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, [Bomati-Miguel, O.] Univ Cadiz, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, [Fernandez-Ponce, C.] Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz, Spain, [Fernandez-Cisnal, R.] Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz, Spain, [Garcia-Cozar, F.] Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz, Spain, [Fernandez-Ponce, C.] Inst Biomed Res Cadiz INIBICA, Cadiz, Spain, [Fernandez-Cisnal, R.] Inst Biomed Res Cadiz INIBICA, Cadiz, Spain, [Garcia-Villar, C.] Inst Biomed Res Cadiz INIBICA, Cadiz, Spain, [Garcia-Cozar, F.] Inst Biomed Res Cadiz INIBICA, Cadiz, Spain, [Tinoco, M.] Univ Complutense Madrid, ICTS Ctr Nacl Microscopia Elect, Madrid 28040, Spain, [Felix, E.] Univ Cadiz, Fac Sci, Dept Condensed Matter Phys, Cadiz 11510, Spain, [Litran, R.] Univ Cadiz, Fac Sci, Dept Condensed Matter Phys, Cadiz 11510, Spain, [Bomati-Miguel, O.] Univ Cadiz, Fac Sci, Dept Condensed Matter Phys, Cadiz 11510, Spain, [Pfaff, C.] Univ Vienna, Fac Earth Sci Geog & Astron, Dept Palaeontol, A-1090 Vienna, Austria, [Kriwet, J.] Univ Vienna, Fac Earth Sci Geog & Astron, Dept Palaeontol, A-1090 Vienna, Austria, [Natividad, E.] Univ Zaragoza, Inst Nanociencia & Mat Aragon INMA, CSIC, EINA, Edificio Torres Quevedo,Maria de Luna 3, Zaragoza 50018, Spain, [Garcia-Villar, C.] Hosp Univ Puerta del Mar, Radiol Dept, Ana Viya Ave 21, Cadiz 11009, Spain, Spanish Ministry of Economy and Competitiveness, Consejeria Salud y Familias. JA Spain, Consejeria Economia, Conocimiento, Empresas y Universidad. JA Spain, MCIN/AEI, MINECO/FEDER, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Solvothermal process Enhancement Process Chemistry and Technology Nanoprobe Ytterbium -iron nanoparticles Surfaces Coatings and Films Electronic Optical and Magnetic Materials Computed-tomography Materials Chemistry Ceramics and Composites Functionalization Multiplatform contrast agents Mri Ct
Zdroj:	Zaguán. Repositorio Digital de la Universidad de Zaragoza instname
Popis:	A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nanoparticles present similar composition, with YbFeO3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over -saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine. This work was supported by the Spanish Ministry of Economy and Competitiveness (MAT2015-67354-R) for O.B-M and PID2020-117544RB-I00, for F.G-CPECART-0096-2020, Consejería Salud y Familias. JA Spain; and P20_01293, Consejería Economía, Conocimiento, Empresas y Universidad. JA Spain; for F.G-C; Spanish MCIN/AEI/10.13039/501100011033 (project PID2020-118329RB-I00) for E.N; and MINECO/ FEDER Project MAT2017-87579-R. The authors would like to thank the Nanotechnology in translational hyperthermia RED2018-102626-T network.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615af25c2e1499cf9d0b6409573abadb https://hdl.handle.net/10668/22080 Zobrazit plný text záznamu