The prognostic value of tumor mitotic rate in children and adolescents with cutaneous melanoma: A retrospective cohort study

Autor: Serigne Lo, Lodewijka H. J. Holtkamp, James S. Wilmott, Richard A. Scolyer, Norbertus A. Ipenburg, Ricardo E. Vilain, John F. Thompson, Omgo E. Nieweg
Rok vydání: 2019
Předmět:
Oncology
Male
SINGLE-INSTITUTION EXPERIENCE
PEDIATRIC MELANOMA
Skin Neoplasms
MULTICENTER
mitotic rate
MALIGNANT-MELANOMA
030207 dermatology & venereal diseases
0302 clinical medicine
Prospective Studies
dermatopathology
Child
Melanoma
AMERICAN JOINT COMMITTEE
Skin
OUTCOMES
Hazard ratio
Sentinel node
Prognosis
Primary tumor
030220 oncology & carcinogenesis
Child
Preschool
Lymphatic Metastasis
oncology
SURVIVAL
Female
medicine.medical_specialty
recurrence
Adolescent
Sentinel lymph node
Dermatology
Disease-Free Survival
Breslow Thickness
03 medical and health sciences
Young Adult
AGE
children
Internal medicine
medicine
Mitotic Index
Humans
Retrospective Studies
mitosis
business.industry
Sentinel Lymph Node Biopsy
Infant
Retrospective cohort study
medicine.disease
pediatric
YOUNG
Cutaneous melanoma
pathology
Lymph Nodes
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: Journal of The American Academy of Dermatology, 82(4), 910-919. MOSBY-ELSEVIER
Journal of the American Academy of Dermatology, 82(4), 910-919. MOSBY-ELSEVIER
ISSN: 1097-6787
0190-9622
Popis: Background: Mitotic rate is a strong predictor of outcome in adult patients with primary cutaneous melanoma, but for children and adolescent patients this is unknown. Objective: We sought to assess the prognostic value of primary tumor mitotic rate in children and adolescents with primary melanoma. Methods: This was a cohort study of 156 patients who were 2 in 104 patients (67%) and correlated with increasing Breslow thickness. A positive sentinel node was found in 23 of 61 patients (38%) in whom a sentinel lymph node biopsy specimen was obtained. The median follow-up was 61 months. Five-year melanoma-specific and recurrence-free survival rates were 91% and 84%, respectively. Mitotic rate was a stronger predictor of outcome than tumor thickness and was the only factor independently associated with recurrence-free survival. Limitations: This research was conducted at a single institution and the sample size was small. Conclusion: Mitotic rate is an independent predictor of recurrence-free survival in children and adolescents with clinically localized melanoma.
Databáze: OpenAIRE
Externí odkaz: