Effects of interleukin-6 produced in coronary circulation on production of C-reactive protein and coronary microvascular resistance
| Autor: | Toshiro Nagoshi, Junji Kawagoe, Riichirou Kawamoto, Tanenao Eto, Haruhiko Date, Takahiro Sumi, Takuroh Imamura, Tetsunori Ishikawa, Hisamitsu Onitsuka |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Coronary Artery Disease Great cardiac vein Coronary artery disease Microvascular resistance Coronary circulation Left coronary artery Coronary Circulation medicine.artery Internal medicine medicine Humans Interleukin 6 Aged Aged 80 and over biology Interleukin-6 business.industry C-reactive protein Middle Aged medicine.disease C-Reactive Protein medicine.anatomical_structure Cytokine biology.protein Cardiology Female Vascular Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 95:849-852 |
| ISSN: | 0002-9149 |
| Popis: | We measured plasma levels of interleukin-6 and C-reactive protein at the orifice of the left coronary artery and at the great cardiac vein in patients who had coronary artery disease and those who had angiographically normal coronary arteries (controls). We also measured coronary microvascular resistance in the control group. We found increased levels of interleukin-6 in the coronary circulation of patients who had coronary artery disease compared with controls. This increase correlated with C-reactive protein production in the coronary circulation and coronary microvascular resistance. These findings suggest that a localized cytokine/inflammatory pathway functions in the coronary circulation and that interleukin-6 is involved in modulating coronary vascular tone. |
| Databáze: | OpenAIRE |
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