Expression of programmed death-ligand 1 protein in pulmonary squamous cell carcinoma correlates with tumour necrosis but not with tumour differentiation
| Autor: | Marian Grendar, Anna Farkasova, Zuzana Kviatkovská, Lukáš Plank, Alena Liskova, Zdenko Huťka, Vladimír Tancoš |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Lung Neoplasms Necrosis Cell B7-H1 Antigen Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Biomarkers Tumor medicine Carcinoma Humans Basal cell Lung cancer Lung business.industry General Medicine medicine.disease Ligand (biochemistry) 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Carcinoma Squamous Cell Immunohistochemistry medicine.symptom business |
| Zdroj: | Journal of Clinical Pathology. 75:373-378 |
| ISSN: | 1472-4146 0021-9746 |
| Popis: | AimsPulmonary squamous cell carcinoma (SqCC) represents the second most common non-small cell lung carcinoma type. The mechanisms which regulate programmed death ligand 1 (PD-L1) expression in this form of lung cancer are not fully elucidated yet.MethodsWe immunohistochemically determined the level of PD-L1 expression using the Tumour Proportion Score system in surgical resections of 133 patients with pulmonary SqCC. The results from PD-L1 immunohistochemistry were analysed in relation to tumour differentiation and the presence of necrotic areas comprising at least 20% of the tumour mass.ResultsNo significant differences in terms of PD-L1 expression were found between SqCC subtypes as defined by the current WHO classification: better differentiated, keratinising tumours (12/24, 50.0 %) compared with less differentiated, non-keratinising and basaloid forms (62/109, 56.9 %) were PD-L1 positive in a comparable proportion of cases (p=0.1903). Contrary to that, SqCCs with the presence of necrosis (51/61, 83.6 %) had significantly more PD-L1-positive cases (pConclusionsWe demonstrated that PD-L1 expression in pulmonary SqCCs does not correlate with the traditionally defined degree of differentiation of these tumours. On the other hand, we found a significant association between the positive result of PD-L1 immunohistochemistry and tumour necrosis. Further investigation regarding the role of hypoxic pathways as presumable inducers of PD-L1 expression in pulmonary SqCCs might contribute to the understanding of this phenomenon. |
| Databáze: | OpenAIRE |
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