Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)
| Autor: | Huasheng Liu, Bo Cheng, Hua Zhang, Guanghua Xiong, Tianzhu Shen, Huiqiang Lu, Zigang Cao, Lufang Zou, Xinjun Liao, Juhua Xiao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Embryo
Nonmammalian Environmental Engineering Health Toxicology and Mutagenesis 0208 environmental biotechnology Danio Developmental toxicity Embryonic Development 02 engineering and technology 010501 environmental sciences 01 natural sciences Immune system Nitriles medicine Animals Environmental Chemistry Yolk sac Zebrafish 0105 earth and related environmental sciences biology Public Health Environmental and Occupational Health JAK-STAT signaling pathway General Medicine General Chemistry biology.organism_classification Pollution 020801 environmental engineering Cell biology medicine.anatomical_structure Apoptosis Butanes Signal transduction Water Pollutants Chemical |
| Zdroj: | Chemosphere. 263:127849 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2020.127849 |
| Popis: | Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and molecular biology methods were used to study the effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish. After cyhalofop-butyl exposed, the results showed that the zebrafish embryos had shorter length, yolk sac edema, significantly reduced number of immune cells, inflammatory response and immunocytes apoptosis. In addition, we found that the expression of immune-related genes and pro-apoptotic genes were up-regulated, and the JAK-STAT signaling pathway mediated the immunotoxicity induced by cyhalofop-butyl. Therefore, our results indicate that cyhalofop-butyl has developmental toxicity and immunotoxicity to zebrafish, and this study offer new contents for the effects of cyhalofop-butyl exposure on aquatic organisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect