A Dose-Response Study in Man of the Metabolism of Enflurane Used as a Supplement
| Autor: | J. E. Shumacher, J. H. Sharp, Lowry Cj, Michael J. Cousins |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Methyl Ethers Adult male medicine.drug_class Nitrous Oxide Critical Care and Intensive Care Medicine Enflurane Fluorides chemistry.chemical_compound medicine Humans Dose-Response Relationship Drug business.industry Muscle relaxant Nitrous oxide Metabolism Dose Response Study Anesthesiology and Pain Medicine chemistry Anesthesia Halothane Anesthesia Inhalation business medicine.drug Surgical patients |
| Zdroj: | Anaesthesia and Intensive Care. 5:198-206 |
| ISSN: | 1448-0271 0310-057X |
| DOI: | 10.1177/0310057x7700500302 |
| Popis: | The metabolism of enflurane, used as a supplement to muscle relaxant and nitrous oxide anaesthesia, was studied in 19 healthy adult male surgical patients; seven control patients received halothane. Patients receiving enflurane were randomly allocated to three groups: Group I—1/2 MAC for 1/2 hour (dosage=1/4 MAC hour) Group II—1/2 MAC for 2 hours (dosage=1 MAC hour) Group III—1/2 MAC for 4 hours (dosage=2 MAC hours) Metabolism of enflurane to inorganic fluoride (F-) was indicated by elevated serum F-concentration and elevated urinary excretion of F-. Peak serum F- concentration was measured in samples collected immediately at the end of enflurane anaesthesia and fell thereafter, approaching pre-operative levels at 48 hours; mean peak serum F- was 23·6± 4·2 μmol/l after 2 MAC hours of enflurane, 17·7±2·8 μmol/l after 1 MAC hour and 10·5± 0·9 μmol/l after 1/4 MAC hour. Nephrotoxic levels of serum F- (50 μmol/l) were not reached in any patient. Post anaesthetic renal function, including response to vasopressin, was normal in all groups. A dose-response relationship between enflurane dose and F- in serum and urine was established. |
| Databáze: | OpenAIRE |
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