Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro
| Autor: | I. I. Faingold, Sergey M. Aldoshin, A. P. Sadkov, R. A. Kotel’nikova, Natalia A. Sanina, D. A. Poletaeva, A. V. Smolina, Yu. V. Soldatova, O. V. Pokidova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antioxidant
Monoamine Oxidase Inhibitors medicine.medical_treatment Iron Biophysics Thiosulfates Mitochondrion Biochemistry Catalysis Electron Transport Complex IV Mitochondrial Proteins chemistry.chemical_compound Mice medicine Cytochrome c oxidase Animals Iron complex Monoamine Oxidase Thiosulfate biology Brain General Chemistry General Medicine In vitro Mitochondria chemistry biology.protein Nitrogen Oxides Monoamine oxidase A |
| Zdroj: | Doklady. Biochemistry and biophysics. 488(1) |
| ISSN: | 1608-3091 |
| Popis: | The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in animal brain mitochondria in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|