The natural xanthone α-mangostin reduces oxidative damage in rat brain tissue
| Autor: | Octavio González-Cuahutencos, Luis Rubén Miranda-Ramírez, José Pedraza-Chaverri, Verónica Valdivia-Cerda, Rachel Mata, Abel Santamaría, Berenice Márquez-Valadez, Isabel Rivero-Cruz, Verónica Pérez de la Cruz, Rafael Lugo-Huitrón |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Xanthones Medicine (miscellaneous) Mitochondrion medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Ferrous chemistry.chemical_compound Xanthone medicine Animals Ferrous Compounds Rats Wistar Nutrition and Dietetics Dose-Response Relationship Drug Toxin General Neuroscience Brain General Medicine Quinolinic Acid Nitro Compounds Rat brain Quinolinate Mitochondria Rats Oxidative Stress chemistry Biochemistry Lipid Peroxidation Propionates Oxidative stress Synaptosomes Quinolinic acid |
| Zdroj: | Nutritional Neuroscience. 12:35-42 |
| ISSN: | 1476-8305 1028-415X |
| Popis: | The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radical generator (ferrous sulfate), an excitotoxic agent (quinolinate), and a mitochondrial toxin (3-nitropropionate). alpha-Mangostin decreased the lipoperoxidative action of FeSO(4) in both preparations in a concentration-dependent manner, and completely abolished the peroxidative effects of quinolinate, 3-nitropropionate and FeSO(4) + quinolinate at all concentrations tested. Interestingly, when tested alone in brain homogenates, alpha-mangostin significantly decreased the lipoperoxidation even below basal levels. alpha-Mangostin also prevented the decreased reductant capacity of mitochondria in synaptosomal fractions. Our results suggest that alpha-mangostin exerts a robust antiperoxidative effect in brain tissue preparations probably through its properties as a free radical scavenger. In light of these findings, this antioxidant should be tested in other neurotoxic models involving oxidative stress. |
| Databáze: | OpenAIRE |
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