A new approach for the enzymatic estimation of infarct size: serum peak creatine kinase and time to peak creatine kinase activity
| Autor: | Akinori Takizawa, Masao Nagao, Jiro Kubota, Shingo Omote, Minoru Horie, Shinichiro Nishida, Hirofumi Yasue |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty Cardiac Catheterization Time Factors medicine.medical_treatment Myocardial Infarction Revascularization Internal medicine medicine Humans Myocardial infarction Creatine Kinase Aged Ejection fraction biology business.industry Heart Stroke Volume Thrombolysis Stroke volume Middle Aged medicine.disease Prognosis Heart catheterization biology.protein Cardiology Creatine kinase Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 57(1) |
| ISSN: | 0002-9149 |
| Popis: | The relations of several creatine kinase (CK) variables to angiographic left ventricular ejection fraction and abnormally contracting segments in the chronic phase were examined in 2 groups of patients with a first anterior acute myocardial infarction. In group A (n = 22), emergency coronary angiography was performed and nonsurgical early reperfusion was attempted. Such an early revascularization, which was considered partially present in group B (n = 16), which received conventional therapy, shifted the CK time-activity curve to the left and altered its relation to angiographic cardiac function. At similar levels of peak CK, myocardial damage was significantly smaller in patients with successful thrombolysis than in those with unsuccessful reperfusion and conventional therapy (p less than 0.01). In patients whose infarct was considered to be moderate according to peak CK (1,000 to 3,000 U/liter), there was significant correlation between time to peak CK and left ventricular ejection fraction or percent abnormally contracting segments irrespective of their group. The results suggest that one should take into account rapid washout and shorter time to peak CK when estimating enzymatic infarct size in humans. The multivariate analysis of cardiac function with peak CK and time to peak CK resulted in a closer correlation in all patients. Such a correction in the time to peak CK may be a clinically useful approach for better interpretation of infarct size. |
| Databáze: | OpenAIRE |
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