The Effect of Oral Leucine on Protein Metabolism in Adolescents with Type 1 Diabetes Mellitus

Autor: Vardhini Desikan, Izolda Mileva, Jeremy Garlick, AndrewH Lane, ThomasA Wilson, MargaretA McNurlan
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: International Journal of Pediatric Endocrinology, Vol 2010, Iss 1, p 493258 (2010)
ISSN: 1687-9856
1687-9848
Popis: Lack of insulin results in a catabolic state in subjects with insulin-dependent diabetes mellitus which is reversed by insulin treatment. Amino acid supply, especially branched chain amino acids such as leucine, enhances protein synthesis in both animal and human studies. This small study was undertaken to assess the acute effect of supplemental leucine on protein metabolism in adolescents with type 1 diabetes. L-[1-13C] Leucine was used to assess whole-body protein metabolism in six adolescent females (16–18 yrs) with type 1 diabetes during consumption of a basal diet (containing 58 μmoles leucine/kg/h) and the basal diet with supplemental leucine (232 μmoles leucine/kg/h). Net leucine balance was significantly higher with supplemental leucine ( μmoles leucine/kg body weight/hr) than with the basal diet (, ) due to reduced protein degradation ( μmoles leucine/kg body weight/hr) compared to the basal diet (, ).
Databáze: OpenAIRE
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