Mesenchymal stem cell therapy in hypertrophic and keloid scars
| Autor: | K. T. Matthew Seah, Jessie Shea, Wasim S. Khan, Adam Hatoum, Kendrick To, Charles M. Malata, Christine Bojanic |
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| Přispěvatelé: | To, Kendrick [0000-0001-9262-7190], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Keloid scars medicine.medical_specialty Histology Cicatrix Hypertrophic Scars Pain Disease Review Mesenchymal Stem Cell Transplantation Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Scar medicine Animals Humans Wound regeneration ComputingMilieux_MISCELLANEOUS Wound Healing business.industry Mesenchymal stem cell Cell Biology Dermatology Clinical trial Transplantation 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Keloid Mesenchymal stem cells Animal studies medicine.symptom Wound healing business |
| Zdroj: | Cell and Tissue Research |
| ISSN: | 1432-0878 |
| Popis: | Funder: University of Cambridge Scars are the normal outcome of wound repair and involve a co-ordinated inflammatory and fibrotic process. When a scar does not resolve, uncontrolled chronic inflammation can persist and elicits excessive scarring that leads to a range of abnormal phenotypes such as hypertrophic and keloid scars. These pathologies result in significant impairment of quality of life over a long period of time. Existing treatment options are generally unsatisfactory, and there is mounting interest in innovative cell-based therapies. Despite the interest in mesenchymal stem cells (MSCs), there is yet to be a human clinical trial that investigates the potential of MSCs in treating abnormal scarring. A synthesis of existing evidence of animal studies may therefore provide insight into the barriers to human application. The aim of this PRISMA systematic review was to evaluate the effectiveness of MSC transplantation in the treatment of hypertrophic and keloid scars in in vivo models. A total of 11 case-control studies were identified that treated a total of 156 subjects with MSCs or MSC-conditioned media. Ten studies assessed hypertrophic scars, and one looked at keloid scars. All studies evaluated scars in terms of macroscopic and histological appearances and most incorporated immunohistochemistry. The included studies all found improvements in the above outcomes with MSC or MSC-conditioned media without complications. The studies reviewed support a role for MSC therapy in treating scars that needs further exploration. The transferability of these findings to humans is limited by factors such as the reliability and validity of the disease model, the need to identify the optimal MSC cell source, and the outcome measures employed. |
| Databáze: | OpenAIRE |
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