A potential role of lymphangiogenesis for peripheral nerve injury and regeneration
| Autor: | Florian S. Frueh, Pietro Giovanoli, Dominic Power, Matthias W. Laschke, Maurizio Calcagni, Epameinondas Gousopoulos, Emmanuel Ampofo |
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| Přispěvatelé: | University of Zurich, Frueh, Florian S |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
0301 basic medicine
Microsurgery 610 Medicine & health 2700 General Medicine Neurosurgical Procedures 03 medical and health sciences 0302 clinical medicine Peripheral nerve Peripheral Nerve Injuries Medicine Animals Humans Peripheral Nerves Lymphangiogenesis 10266 Clinic for Reconstructive Surgery business.industry Regeneration (biology) General Medicine Plastic Surgery Procedures Peripheral Nerve Regeneration Sensory function 030104 developmental biology Peripheral nerve injury Neuropathic pain Neuralgia Schwann Cells business Neuroscience 030217 neurology & neurosurgery |
| DOI: | 10.22028/d291-39359 |
| Popis: | Traumatic peripheral nerve injuries are common and socioeconomically highly relevant. Despite significant microsurgical advances, the results of surgical reconstruction are still far from optimal and the rate of life-long complications, such as impaired motor and sensory function or neuropathic pain, is high. Moreover, the regeneration of peripheral nerves is a complex and fragile process that is not yet completely understood. Hence, there is an urgent need to further elucidate the underlying biological mechanisms. Herein, we propose that the neural lymphatic vasculature and lymphangiogenesis play an essential role in both peripheral nerve injury and regeneration and discuss hypothetical mechanisms implementing the current literature. Finally, specific research approaches to test our hypothesis are introduced. |
| Databáze: | OpenAIRE |
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