Expression of c-kit (CD117) in Spitz nevus and malignant melanoma
| Autor: | James E. Fitzpatrick, Y. Isabel Zhu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Skin Neoplasms Dermatology Melanocyte migration Pathology and Forensic Medicine Diagnosis Differential Nevus Epithelioid and Spindle Cell medicine Biomarkers Tumor Humans skin and connective tissue diseases Melanoma Retrospective Studies biology CD117 Differential staining business.industry Anatomical pathology medicine.disease Spitz nevus Immunohistochemistry digestive system diseases Staining Proto-Oncogene Proteins c-kit biology.protein Melanocytes business |
| Zdroj: | Journal of cutaneous pathology. 33(1) |
| ISSN: | 0303-6987 |
| Popis: | Background: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions. The purpose of this study is to compare CD117 immunohistological staining in Spitz nevus versus malignant melanoma, to determine whether CD117 can aid in the diagnosis of these two lesions. Methods: CD-117 immunohistological staining was performed in 22 clinically and pathologically diagnosed pigmented lesions including 9 cases of Spitz nevus, 10 cases of primary MM and 3 cases of metastatic melanoma. Results: There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas. However staining of metastatic melanomas is less than dermal staining of primary MM and Spitz nevus. Conclusions: CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primary MM. On the other hand, CD 117 may be useful in differentiating metastatic melanoma from primary melanoma in patients who had a history of melanoma and who present with new dermal lesions. |
| Databáze: | OpenAIRE |
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