Association Between Tooth Loss and Longitudinal Changes in B-Type Natriuretic Peptide Over 5 Years in Postmenopausal Women: The Nagahama Study
| Autor: | Marina Kashiwagi, Kazuwa Nakao, Takuma Watanabe, Toru Yamazaki, Shigeki Yamanaka, Kazumasa Nakao, Takehisa Fukuhara, Chisa Umebachi, Kazuhisa Bessho, Takahisa Kawaguchi, Takeo Nakayama, Shizuko Fukuhara, Kazuya Setoh, Keita Asai, Fumihiko Matsuda, Katsu Takahashi, Satoshi Morita, Yasuharu Tabara, Asumi Kakeno |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis medicine.drug_class Myocardial Infarction Angina Tooth Loss Diabetes mellitus Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Tooth loss Diabetes Mellitus Humans Prospective Studies Prospective cohort study Heart Failure business.industry General Medicine medicine.disease Confidence interval Postmenopause Heart failure Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Current problems in cardiology. 47(10) |
| ISSN: | 1535-6280 |
| Popis: | BACKGROUND: There is disparity between the sexes in cardiovascular diseases including heart failure (HF). This study aimed to investigate the effect of periodontal disease (PD) on plasma B-type natriuretic peptide (BNP) concentration across sex, age, and menopausal status, as well as the interaction effect of MT and diabetes mellitus (DM) on BNP. METHODS: This large-scale prospective cohort study enrolled 7, 539 individuals with no myocardial infarctions or angina pectoris at baseline from the general Japanese population. The association between baseline number of missing teeth (MT) and the longitudinal changes in BNP over 5 years (ΔBNP) was evaluated according to sex and menopausal status. RESULTS: Among 7, 539 participants, 3, 190 were postmenopausal women with a mean age ± standard deviation of 61.1 ± 7.6 at baseline. Multivariate analysis revealed a positive association between MT and ΔBNP among postmenopausal women even after adjusting for covariates, including traditional HF risk factors (coefficient, 0.210; 95% confidence interval [CI], 0.107 to 0.312; P 50. Including an interaction term (MT × DM) in the multivariate model revealed a positive interaction between MT and DM in ΔBNP among postmenopausal women (coefficient for interaction, 1.365; 95% CI, 0.902 to 1.827; P for interaction |
| Databáze: | OpenAIRE |
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