Prostate-specific antigen and its derivatives in young adults occupationally exposed to quarry pollutants in southeastern Nigeria
| Autor: | Uchechukwu Dimkpa, Joel C. Onyeanusi, Chinwe O. Ewenighi, Gladys O. Onoh, Uchechukwu Ezeugwu, Adejumo Babtunde, Linus U. M. Onoh |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Time Factors Health Toxicology and Mutagenesis Nigeria urologic and male genital diseases Toxicology Mining Young Adult 03 medical and health sciences Southeastern Nigeria 0302 clinical medicine Air pollutants Occupational Exposure Environmental health Humans Medicine Young adult General Environmental Science Pollutant Air Pollutants business.industry Free psa Public Health Environmental and Occupational Health Prostate-Specific Antigen 030210 environmental & occupational health Prostate-specific antigen Case-Control Studies 030220 oncology & carcinogenesis Occupational exposure business Total psa |
| Zdroj: | Archives of Environmental & Occupational Health. 72:258-263 |
| ISSN: | 2154-4700 1933-8244 |
| DOI: | 10.1080/19338244.2016.1207593 |
| Popis: | To evaluate the level of total prostate-specific antigen (PSA) and effect of duration of exposure to pollutants in quarry workers, 5 mls of blood sample was collected from participants: 72 male quarry workers exposed to quarry pollutants and 72 unexposed controls. PSA estimations were done using the principle of ELISA. Mean total PSA, free PSA, and free-total PSA ratio levels of quarry workers did not differ from those of controls and was below the cutoff for the risk of prostate diseases. Higher mean total PSA and free PSA were observed in workers exposed for > 3 years compared to the unexposed control and workers exposed for ≤ 3 years. Age-adjusted linear regression indicated significant association (R = 0.515; p < .001) between the duration of exposure and total PSA level in quarry workers. This study suggests that longer duration of exposure to the quarry pollutants may elevate PSA level if precautions are not taken to minimize dose of exposure. |
| Databáze: | OpenAIRE |
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