The impact of the time to start radiation therapy on overall survival in newly diagnosed glioblastoma
| Autor: | Marcella Coelho Mesquita, Gustavo Nader Marta, Edla Renata Cavalcante, Rossana Verónica Mendoza López, Olavo Feher, Vanessa Montes Santos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Time-to-Treatment Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy Overall survival Humans Medicine Aged Retrospective Studies Temozolomide medicine.diagnostic_test Brain Neoplasms business.industry Standard treatment Retrospective cohort study Chemoradiotherapy Middle Aged medicine.disease Survival Analysis Radiation therapy Treatment Outcome Neurology 030220 oncology & carcinogenesis Female Neurology (clinical) Glioblastoma business 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 143:95-100 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-019-03137-8 |
| Popis: | The standard treatment for newly diagnosed glioblastoma includes maximal safe surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) and maintenance TMZ. The impact of time to start radiation therapy (TRT) on overall survival (OS) in glioblastoma patients is controversial. The study aimed to evaluate the impact of TRT on OS in patients diagnosed with glioblastoma who received standard treatment. In this retrospective study, we included patients with confirmed diagnosis of glioblastoma treated from 2011 to 2016. TRT was defined as the time between surgery (biopsy or resection) and the first day of radiation therapy. The endpoint was OS. The patients were divided according to the TRT in three categories |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink