Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions
| Autor: | Andrey Yu. Burago, E. A. Velikanova, Sergey E. Peltek, Alexandr A. Vladimirov, S. A. Sozinov, A. V. Frolov, Anton G. Kutikhin, O. S. Efimova, Valentina Yu. Malysheva, Anna N. Popova, Anton K Gutakovsky, Tatiana V. Glushkova, Elena B. Brusina, Olga Barbarash, Alexander A. Lomzov, Arseniy E. Yuzhalin, V. V. Borisov, Viktor Yu. Dolgov, E.V. Grigoriev, D. V. Pyshnyi, Zinfer R. Ismagilov, Vera G. Matveeva, Daria K. Shishkova, D. M. Russakov, Yuriy A. Zhivodkov, A. S. Golovkin, Evgeniy A. Demidov, Dmitriy E. Filip’ev, Viatcheslav F. Dolganyuk, R. A. Mukhamadiyarov, Larisa V. Antonova, Olga Babich |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Calcium Phosphates chemistry.chemical_element Apoptosis 030204 cardiovascular system & hematology Biology Calcium Article Phosphates 03 medical and health sciences 0302 clinical medicine Calcification Physiologic Cardiovascular calcification In vivo Biomimetic Materials medicine Humans Multidisciplinary Endothelial Cells medicine.disease In vitro Plaque Atherosclerotic Cell biology 030104 developmental biology surgical procedures operative chemistry Biochemistry Toxicity Salts Function (biology) Calcification circulatory and respiratory physiology |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Calcium phosphate bions (CPB) are biomimetic mineralo-organic nanoparticles which represent a physiological mechanism regulating the function, transport and disposal of calcium and phosphorus in the human body. We hypothesised that CPB may be pathogenic entities and even a cause of cardiovascular calcification. Here we revealed that CPB isolated from calcified atherosclerotic plaques and artificially synthesised CPB are morphologically and chemically indistinguishable entities. Their formation is accelerated along with the increase in calcium salts-phosphates/serum concentration ratio. Experiments in vitro and in vivo showed that pathogenic effects of CPB are defined by apoptosis-mediated endothelial toxicity but not by direct tissue calcification or functional changes in anti-calcification proteins. Since the factors underlying the formation of CPB and their pathogenic mechanism closely resemble those responsible for atherosclerosis development, further research in this direction may help us to uncover triggers of this disease. |
| Databáze: | OpenAIRE |
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