Fate of the mate: the influence of delayed graft function in renal transplantation on the mate recipient
| Autor: | A. M. Jevnikar, Norman Muirhead, Andrew A. House, J. L. Mahon, J. F. Johnson |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Time Factors Urinary system Urology Renal function Delayed Graft Function Single Center Cohort Studies medicine Immunology and Allergy Humans Pharmacology (medical) Spouses Kidney transplantation Retrospective Studies Kidney Transplantation business.industry Graft Survival Panel reactive antibody Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery medicine.anatomical_structure Treatment Outcome Female business Glomerular Filtration Rate |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 9(8) |
| ISSN: | 1600-6143 |
| Popis: | Delayed graft function (DGF) in a deceased-donor renal recipient is associated with allograft dysfunction 1-year posttransplant. There is limited research about the influence to allograft function on the mate of a DGF recipient over time. Using a retrospective cohort design, we studied 55 recipients from a single center. The primary outcome was the change in glomerular filtration rate (GFR) 1-year posttransplant. The secondary outcome was the GFR at baseline. We found that mates to DGF recipients had a mean change in GFR 1-year posttransplant of −11.2 mL/min, while the control group had a mean change of −0.4 mL/min. The difference in the primary outcome was significant (p = 0.025) in a multivariate analysis, adjusting for cold ischemic time, panel reactive antibody level, allograft loss, human leukocyte antibody (HLA)-B mismatches and HLA-DR mismatches. No significant difference between groups was found in baseline GFR. In conclusion, mates to DGF recipients had a significantly larger decline in allograft function 1-year posttransplant compared to controls with similar renal function at baseline. We believe strategies that may preserve allograft function in these‘at-risk’recipients should be developed and tested. |
| Databáze: | OpenAIRE |
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