Synthesis and Solubility of Collagen in Rats during Recovery after High-dose Cyclophosphamide Administration
| Autor: | Henrik Wie, Eva Imislund Beck |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cyclophosphamide Serum albumin Connective tissue Toxicology Mineralization (biology) Bone and Bones Hydroxyproline chemistry.chemical_compound White blood cell Internal medicine medicine Animals Solubility Serum Albumin Pharmacology biology business.industry Phosphorus Rats Inbred Strains Metabolism Rats Surgery Endocrinology medicine.anatomical_structure chemistry biology.protein Calcium Collagen business medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 48:294-299 |
| ISSN: | 0001-6683 |
| Popis: | The metabolism of collagen and mineral was studied during a nine-day postmedicational period in young, male rats receiving high-dose intraperitoneal cyclophosphamide treatment every second day for 12 days. Two days after ending medication the white blood cell counts (WBC) were reduced by about 70%. Both synthesis and solubility of collagen were suppressed by the present medication 2 days after termination of treatment. This suppression continued throughout the 9-day postmedicational period in bones, whereas in connective tissue of porous, ceramic implants both total collagen and the amount of salt soluble collagen regained normal values 9 days after cessation of treatment. Increased mineralization was found 2 days after ending medication and this high degree of mineralization persisted during the postmedicational period studied. Serum albumin levels were reduced and no increases were detected during the postmedicational period. The suggestion is made that the general protein synthesis is affected by high-dose cyclophosphamide administration. |
| Databáze: | OpenAIRE |
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