Ginseng berry extract enhances metformin efficacy against obesity and hepatic steatosis in mice fed high-fat diet through increase of metformin uptake in liver
| Autor: | Junjeong Choi, Hojun Kim, Young Hee Choi, Han Seok Choi, Hee-Sung Chae, Young-Won Chin, Byoung Hon You |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Hepatic steatosis endocrine system diseases Medicine (miscellaneous) Inflammation Ginseng Internal medicine Enhancer binding medicine TX341-641 Obesity Glycemic Nutrition and Dietetics Adiponectin business.industry Nutrition. Foods and food supply Organic cation transporter nutritional and metabolic diseases medicine.disease Metformin Endocrinology High-fat diet Ginseng berry extract medicine.symptom Steatosis business Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 62, Iss, Pp-(2019) |
| ISSN: | 1756-4646 |
| Popis: | Ginseng berry extract contains plenty of ginsenosides showing anti-obesity and anti-hyperglycemic activities. Regarding that long-term intakes of herbal products to control metabolic disorders as popular alternatives have become popular, ginseng berry extract plus metformin is an attractive item for long-term glycemic control. Herein, we investigated the effect of ginseng berry extract (GBE) or its combination with metformin against obesity and hepatic steatosis in high-fat diet fed mice. GBE altered abnormal features (e.g. body weight, serum profiles, hepatic steatosis/inflammation and fat mass). Concomitantly, GBE increased mRNA levels of adiponectin and CCAAT/enhancer binding protein. All these changes were observed in metformin alone and GBE plus metformin. Moreover, in GBE plus metformin intake, GBE increased organic cation transporter-mediated metformin uptake in liver and mRNA of AMP-activated protein kinase together, which additively ameliorated obesity and hepatic steatosis. Therefore, GBE itself and GBE plus metformin could be useful to regulate metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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