Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
| Autor: | Farhadian, Shelli, Glick, Laura R., Vogels, Chantal B. F., Thomas, Jared, Chiarella, Jennifer, Casanovas-Massana, Arnau, Zhou, Jing, Odio, Camila, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Bermejo, Santos, Fauver, Joseph R., Alpert, Tara, Wyllie, Anne L., Turcotte, Cynthia, Steinle, Matthew, Paczkowski, Patrick, Dela Cruz, Charles, Wilen, Craig, Ko, Albert I., MacKay, Sean, Grubaugh, Nathan D., Spudich, Serena, Barakat, Lydia Aoun |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neurology Pneumonia Viral Central nervous system Encephalopathy Case Report Inflammation Disease lcsh:RC346-429 Article neuroinflammation Betacoronavirus 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Altered Mental Status Seizures medicine Humans Neurochemistry Encephalitis Viral Pandemics lcsh:Neurology. Diseases of the nervous system Neuroinflammation Aged 030304 developmental biology 0303 health sciences SARS-CoV-2 business.industry COVID-19 General Medicine medicine.disease medicine.anatomical_structure Acute Disease Immunology Cytokines Female Neurology (clinical) Neurosurgery medicine.symptom Presentation (obstetrics) Coronavirus Infections business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | BMC neurology, 20(1):248 Research Square article-version (status) pre article-version (number) 1 BMC Neurology, Vol 20, Iss 1, Pp 1-5 (2020) BMC Neurology |
| DOI: | 10.21203/rs.3.rs-28583/v1 |
| Popis: | Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. |
| Databáze: | OpenAIRE |
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