Bos taurus haplotypes segregating in Nellore (Bos indicus) cattle

Autor: Y. T. Utsunomiya, A. A. A. D. Fortunato, M. Milanesi, B. B. Trigo, N. F. Alves, T. S. Sonstegard, J. F. Garcia
Přispěvatelé: Universidade Estadual Paulista (UNESP), International Atomic Energy Agency Collaborating Centre on Animal Genomics and Bioinformatics, AgroPartners Consulting. R. Floriano Peixoto, Personal-PEC. R. Sebastião Lima, Università Della Tuscia, Acceligen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-04-29T08:37:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Brazil is the largest exporter of beef in the world, and most of that beef derives from Nellore cattle. Although considered a zebu breed (Bos indicus), the history of Nellore cattle in Brazil is marked by the importation of bulls from India, the use of a Creole taurine (Bos taurus) maternal lineage to quickly expand the herds and backcrossing to Nellore bulls to recover zebu ancestry. As a consequence, the current Brazilian Nellore population carries an average taurine ancestry of approximately 1%. Although that percentage seems small, some taurine variants deviate substantially from that average, with the better-known cases being the PLAG1-Q haplotype involved with body size variation and the Guarani (PG) polled variant producing hornless animals. Here, we report taurine haplotypes in 9074 Nellore animals genotyped for 539 657 imputed SNP markers. Apart from PLAG1-Q and PG, our analysis further revealed common taurine haplotypes (>3%) spanning genes related to immunity, growth, reproduction and hair and skin phenotypes. Using data from 22 economically important traits, we showed that many of the major QTL previously reported in the breed are at least partially driven by taurine haplotypes. As B. taurus and B. indicus haplotypes are highly divergent, presenting widely different sets of functional variants, our results provide promising targets for future scrutiny in Nellore cattle. Department of Production and Animal Health School of Veterinary Medicine of Araçatuba São Paulo State University, 16050-680 R. Clovis Pestana 793 – Dona Amelia, SP International Atomic Energy Agency Collaborating Centre on Animal Genomics and Bioinformatics, 16050-680 R. Clovis Pestana 793 – Dona Amelia, SP AgroPartners Consulting. R. Floriano Peixoto, 120 – Sala 43A – Centro, SP Personal-PEC. R. Sebastião Lima, 1336 – Centro, MS Department for Innovation in Biological Agro-Food and Forest Systems Università Della Tuscia, Via S. Camillo de Lellis snc Acceligen Department of Preventive Veterinary Medicine and Animal Reproduction School of Agricultural and Veterinarian Sciences São Paulo State University, 14884-900 Via de Acesso Prof. Paulo Donato Castellane s/n, SP Department of Production and Animal Health School of Veterinary Medicine of Araçatuba São Paulo State University, 16050-680 R. Clovis Pestana 793 – Dona Amelia, SP Department of Preventive Veterinary Medicine and Animal Reproduction School of Agricultural and Veterinarian Sciences São Paulo State University, 14884-900 Via de Acesso Prof. Paulo Donato Castellane s/n, SP CAPES: 001 FAPESP: 2010/52030-2 CNPq: 483590/2010-0 CNPq: 560922/2010-8
Databáze: OpenAIRE
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