Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study
| Autor: | Yunhai Tu, Yirou Zang, Xiaozheng Liu, Aiqin Wu, Jia-Wei He, Zhongwei Guo |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Brain activity and meditation Audiology Brain mapping behavioral disciplines and activities lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Gyrus Hamd mental disorders medicine Dementia Humans Cognitive Dysfunction lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Brain Mapping Resting state fMRI medicine.diagnostic_test business.industry Depression Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry medicine.anatomical_structure Neurology Female Neurology (clinical) business Functional magnetic resonance imaging 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Plasticity, Vol 2019 (2019) Neural Plasticity |
| ISSN: | 1687-5443 2090-5904 |
| Popis: | Depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have an increased risk of dementia. It is currently unclear whether the pattern of spontaneous brain activity in patients with MCI differs between subjects with and without depressive symptoms. The current study sought to investigate the features of spontaneous brain activity in MCI patients with depressive symptoms (D-MCI) using coherence regional homogeneity (CReHo) analysis with resting-state functional magnetic resonance imaging (rsfMRI). We obtained rsfMRI data in 16 MCI patients with depressive symptoms and 18 nondepressed MCI patients (nD-MCI) using a 3 T scanner. Statistical analyses were performed to determine the regions in which ReHo differed between the two groups in specific frequency bands, slow-4 (0.027–0.073 Hz) and slow-5 (0.010–0.027 Hz), and typical bands (0.01–0.08 Hz). Correlation analyses were performed between the CReHo index of these regions and clinical variables to evaluate the relationship between CReHo and pathophysiological measures in the two groups. Our results showed that D-MCI patients exhibited significantly higher CReHo in the left Heschl’s gyrus and left thalamus and lower CReHo in the left postcentral gyrus in the typical frequency band. In the slow-4 frequency band, D-MCI patients showed significantly higher CReHo in the left Heschl’s gyrus and left thalamus. In the slow-5 frequency band, D-MCI patients exhibited significantly lower CReHo in the superior medial prefrontal gyrus. In addition, the results revealed that CReHo values in the left thalamus were positively correlated with Hamilton Depression Rating Scale (HAMD) scores in D-MCI patients. These results suggest that the sensorimotor network may be one of the main pathophysiological factors in D-MCI. |
| Databáze: | OpenAIRE |
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