Rab7l1 plays a role in regulating surface expression of toll like receptors and downstream signaling in activated macrophages

Autor:	Rohini Shrivastava, Sivapriya Pavuluri, Sudip Ghosh, Sangita Mukhopadhyay
Rok vydání:	2022
Předmět:	Biophysics Cell Biology Molecular Biology Biochemistry
Zdroj:	Biochemical and biophysical research communications. 640
ISSN:	1090-2104
Popis:	Rab GTPases are known for controlling intracellular membrane traffic in a GTP-dependent manner. Rab7l1, belonging to family of Rab GTPases, is important for both endosomal sorting and retrograde transport. In our previous study, we identified a novel role of Rab7l1 in phagosome maturation. However, its role in regulating macrophage innate-effector signaling and cytokine response is not clearly understood. In this study, we have demonstrated that upon treatment of Rab7l1-knocked-down (Rab7l1-KD) THP-1 macrophages with lipopolysaccharide (LPS) and Pam
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6138b13bb6c4f373164f972954e6f85a https://pubmed.ncbi.nlm.nih.gov/36502628 Zobrazit plný text záznamu Full Text from ScienceDirect