Magnesium lithospermate B improves metabolic changes in high-fat diet-fed rats with metabolic syndrome
| Autor: | Yuan-Hao Lo, Nai-Wei Lai, Yi-Ting Chen, Nan-Hei Lin, Jason T.C. Tzen, Tse-Yu Chung, Ying-Jie Chen, Wen-Ying Chen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Steatosis CD36 Medicine (miscellaneous) Adipokine Salvia miltiorrhiza Proinflammatory cytokine Insulin resistance High fat diets Magnesium lithospermate B Internal medicine medicine TX341-641 Transcription factor Nutrition and Dietetics biology Nutrition. Foods and food supply Chemistry medicine.disease Metabolic syndrome Endocrinology biology.protein Food Science |
| Zdroj: | Journal of Functional Foods, Vol 14, Iss, Pp 163-173 (2015) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2015.01.042 |
| Popis: | Danshen, the roots of Salvia miltiorrhiza, is a natural food and traditional Chinese herb possessing antidiabetic and antilipidaemic activities. In the present study, the beneficial effects and possible mechanisms of Magnesium lithospermate B (MLB), the major soluble constituent in Danshen, were investigated in a rodent model of metabolic syndrome induced by a high-fat diet (HFD). Daily supplementation of MLB improved obesity, hyperlipidaemia, hyperglycaemia, glucose intolerance, insulin resistance, and hepatic steatosis caused by HFD. Mechanistic studies showed that MLB caused a down-regulation of fatty acid transporter CD36 and lipogenic transcription factor sterol regulatory element-binding transcription factor 1c (SREBP1c) expression and an up-regulation of lipolytic transcription factor peroxisome proliferator-activated receptor-α (PPARα) expression and post-receptor insulin signalling. In addition, MLB supplementation attenuated proinflammatory cytokine and adipokine expression. These results suggest that MLB may be an active ingredient contributing to the beneficial effects of Danshen on insulin resistance as well as on metabolic syndrome. |
| Databáze: | OpenAIRE |
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