Analgesic Activity of Morphine Suppository in Rats

Autor:	Takashi Tan, Atsuko Kita, Toshiaki Kadokawa, Hideo Nakamura
Rok vydání:	1990
Předmět:	Male Pharmacology Analgesics Morphine business.industry Suppositories Analgesic Brain Pharmaceutical Science Rectum Rats Inbred Strains Absorption (skin) Suppository Rats medicine.anatomical_structure Rectal administration Animals Medicine Potency business ED50 medicine.drug
Zdroj:	YAKUGAKU ZASSHI. 110:349-353
ISSN:	1347-5231 0031-6903
DOI:	10.1248/yakushi1947.110.5_349
Popis:	Analgesic activity of morphine administered rectally as a suppository was investigated in rats in order to ascertain analgesic activity of morphine suppository. Morphine hydrochloride given rectally as a suppository produced analgesic activity in a dose-related manner in the tail pressure and acetic acid-induced writhing tests, and its potency (ED50 = about 17 and 0.689 mg/kg, respectively) was approximately twice that of morphine hydrochloride administered orally as an aqueous solution. The analgesic action was as durable as that of oral morphine, but its onset was faster. The plasma and brain levels of morphine reached peak until 30 min after rectal administration of morphine suppository, and these time-courses approximately corresponded with that of the analgesic action. These results suggest that morphine given rectally to rats as a suppository produces analgesic action equivalent or superior to orally administered morphine after absorption from the rectum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6135a0c896b1f354c5cdbe51ef4a4125 https://doi.org/10.1248/yakushi1947.110.5_349 Zobrazit plný text záznamu