Renin-like activity in vascular tissue of DOC-salt hypertensive rats
| Autor: | Alberto C. Taquini, Diana Grinspon, Patricia Ruiz, Nidia Basso, Elsa Mangiarua |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Captopril Sodium chemistry.chemical_element Angiotensin-Converting Enzyme Inhibitors Blood Pressure Sodium Chloride medicine.artery Internal medicine Renin–angiotensin system Endopeptidases Internal Medicine medicine Animals Desoxycorticosterone Mesenteric arteries Vascular tissue Aorta business.industry Rats Inbred Strains Arteries Hydrogen-Ion Concentration Rats medicine.anatomical_structure Blood pressure Endocrinology chemistry Hypertension business medicine.drug Artery |
| Zdroj: | Clinical and experimental hypertension. Part A, Theory and practice. 7(9) |
| ISSN: | 0730-0077 |
| Popis: | The presence of isorenin active at the physiological pH was investigated in DOC-salt hypertensive rats. The effect of chronic captopril treatment was analyzed in similarly treated animals and in control rats. The levels of the plasma (PRA) and vascular enzyme (VRLA) were compared with those of untreated control animals. DOC-salt administration was maintained during 4 or 8 weeks. Captopril was given in the drinking fluid beginning 4 days before DOC-salt treatment. Renin-like activity was measured in the aorta and mesenteric arteries. DOC-salt treatment reduced PRA to almost undetectable levels while aorta renin-like enzyme only decreased to 50% at 4 weeks and was not changed at 8 weeks. Isorenin levels in the mesenteric artery did not show any significant variation. Captopril did not prevent the increase in blood pressure due to DOC-salt administration and it induced a significant increase in PRA and in VRLA in control rats whereas it did not increase either - enzyme in DOC-salt treated rats. In summary these results confirm the existence of a vascular isorenin and suggest that both binding and local synthesis of the enzyme could take place in the arterial wall. |
| Databáze: | OpenAIRE |
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