A complex major histocompatibility complexDlocus variant generated by an unusual recombination mechanism in mice
| Autor: | Theodore J. Yun, Roger W. Melvold, Larry R. Pease |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
DNA
Complementary DNA Repair Molecular Sequence Data Locus (genetics) Biology Major histocompatibility complex Mice Complementary DNA Animals Coding region Cloning Molecular Histocompatibility Antigen H-2D Gene Recombination Genetic Genetics chemistry.chemical_classification Genomic Library Multidisciplinary Histocompatibility Antigens Class I H-2 Antigens Nucleic acid sequence Genetic Variation Sequence Analysis DNA Biological Sciences Molecular biology Amino acid Mice Inbred C57BL ComputingMethodologies_PATTERNRECOGNITION chemistry Mutation biology.protein Recombination |
| Zdroj: | Proceedings of the National Academy of Sciences. 94:1384-1389 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.94.4.1384 |
| Popis: | A spontaneous variant of the mouse class I major histocompatibility complexDbgene, designatedDbm28, is characterized. This mutation consists of a cluster of nucleotide substitutions in exon 3 that resembles the product of a classical gene conversion event in that the substituted nucleotides appear to be templated. However,Dbm28is distinctive, because no single donor gene containing the nucleotide sequence of the mutation exists in the genome of the parent strain. The mutation is consistent with the expected result of an interaction of two donor genes at the target locus during a single recombination event. While no known genetic mechanism gives rise to this class of mutation, we have established that 10 percent of spontaneous class I mutations in the mouse major histocompatibility complex have this complex phenotype. This process occurs at theDlocus and theKlocus. The significance of this kind of genetic interaction may extend beyond the major histocompatibility complex and have importance in shaping other multigene families. |
| Databáze: | OpenAIRE |
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