Polyspike and Waves Do Not Predict Generalized Tonic-Clonic Seizures in Childhood Absence Epilepsy
| Autor: | Ryan Cauley, Martina Durner, Steven L. Kugler, David E. Mandelbaum, Deb K. Pal, Esther Vierck |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Electroencephalography Article Epilepsy Childhood absence epilepsy Clinical Protocols Predictive Value of Tests medicine Humans Child Psychiatry Evoked Potentials Survival analysis Valproic Acid medicine.diagnostic_test Incidence (epidemiology) Brain Infant Prognosis medicine.disease nervous system diseases Epilepsy Absence Tonic-clonic seizures Child Preschool Pediatrics Perinatology and Child Health Anticonvulsants Female Epilepsy Tonic-Clonic Neurology (clinical) Age of onset Psychology medicine.drug |
| Zdroj: | Journal of Child Neurology. 25:475-481 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073809341665 |
| Popis: | About 40% of children with childhood absence epilepsy develop generalized tonic-clonic seizures. It is commonly held that polyspike—wave pattern on the electroencephalogram (EEG) can predict this development of generalized tonic-clonic seizures. However, there is no firm evidence in support of this proposition. To test this assumption, we used survival analysis and compared the incidence of generalized tonic-clonic seizures in 115 patients with childhood absence epilepsy having either isolated 3-Hz spike—wave or coexisting 3 Hz and polyspike—waves and other variables. There was no evidence that polyspike—waves predicted development of generalized tonic-clonic seizures in patients with childhood absence epilepsy. Later age of onset (≥8 years) and family histories of generalized tonic-clonic seizures were the only independent predictors. These results have implications for counseling and in the choice of first-line antiepileptic drugs used for childhood absence epilepsy, especially if valproate is chosen based on the observation of polyspike—waves. |
| Databáze: | OpenAIRE |
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