Effects of Mushroom and Chicory Extracts on the Physiology and Shape ofPrevotella intermedia, a Periodontopathogenic Bacterium
| Autor: | Caterina Signoretto, Michael Wilson, Jonathan Pratten, Francesco Tessarolo, Pietro Canepari, Egija Zaura, Gloria Burlacchini, Adele Papetti, Elisabetta Pezzati, Iole Caola, Anna Bertoncelli, Anna Marchi, Peter Lingström, David A. Spratt |
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| Rok vydání: | 2011 |
| Předmět: |
red chicory
Article Subject medicine.drug_class lcsh:Biotechnology Health Toxicology and Mutagenesis Antibiotics lcsh:Medicine medicine.disease_cause Prevotella intermedia Chicory Microbiology Colony-Forming Units Assay Minimum inhibitory concentration lcsh:TP248.13-248.65 mushroom Genetics medicine Periodontopathogenic Bacterium Agaricales Food science Mode of action Molecular Biology Escherichia coli Periodontal Diseases Mushroom biology Plant Extracts lcsh:R General Medicine biology.organism_classification Anti-Bacterial Agents Molecular Weight Microscopy Electron Scanning Molecular Medicine Bacteria Research Article Biotechnology |
| Zdroj: | Journal of Biomedicine and Biotechnology Journal of Biomedicine and Biotechnology, Vol 2011 (2011) |
| ISSN: | 1110-7251 1110-7243 |
| DOI: | 10.1155/2011/635348 |
| Popis: | Contrary to the common assumption that food has a negative impact on oral health, research has shown that several foods contain a number of components with antibacterial and antiplaque activity. These natural compounds may be useful for improving daily oral hygiene. In this study we evaluate the mode of antimicrobial action of fractions of mushroom and red chicory extracts on Prevotella intermedia, a periodontopathogenic bacterium. The minimal inhibitory concentration corresponded to 0.5x compared to the natural food concentration for both extracts. This concentration resulted in a bacteriostatic effect in mushroom extract and in a slightly bactericidal effect in chicory extract. Cell mass continued to increase even after division stopped. As regards macromolecular synthesis, DNA was almost totally inhibited upon addition of either mushroom or chicory extract, and RNA to a lesser extent, while protein synthesis continued. Cell elongation occurred after septum inhibition as documented by scanning electron microscopy and cell measurement. The morphogenetic effects are reminiscent of the mode of action of antibiotics such as quinolones orβ-lactams. The discovery of an antibiotic-like mode of action suggests that these extracts can be advantageously employed for daily oral hygiene in formulations of cosmetic products such as mouthwashes and toothpastes. |
| Databáze: | OpenAIRE |
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