The influence of age‐associated comorbidities on responses to combination antiretroviral therapy in older people living with HIV

Autor: Rossana Ditangco, Tuti Parwati Merati, Jeremy Ross, Junko Tanuma, Mi Young Ahn, Anchalee Avihingsanon, Man Po Lee, Sasisopin Kiertiburanakul, Vohith Khol, Adeeba Kamarulzaman, Awachana Jiamsakul, Suwimon Khusuwan, Sanjay Pujari, Jun Yong Choi, W. W. Wong, Thuy Thanh Pham, Benedict Lim Heng Sim, Winai Ratanasuwan, Oon Tek Ng, Kinh Van Nguyen, Evy Yunihastuti, Romanee Chaiwarith, Nagalingeswaran Kumarasamy, IeDEA Asia-Pacific, Fujie Zhang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Multivariate analysis
Asia
Databases
Factual
age‐associated comorbidity
Anti-HIV Agents
cART
immunological failure
HIV Infections
Comorbidity
03 medical and health sciences
Young Adult
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
mental disorders
medicine
Humans
030212 general & internal medicine
Prospective Studies
Research Articles
Aged
Polypharmacy
Univariate analysis
030505 public health
virological failure
Proportional hazards model
business.industry
Incidence (epidemiology)
Hazard ratio
Public Health
Environmental and Occupational Health
Age Factors
HIV
Middle Aged
medicine.disease
3. Good health
CD4 Lymphocyte Count
Infectious Diseases
Treatment Outcome
Anti-Retroviral Agents
TAHOD (TREAT Asia HIV Observational Database)
Cohort
Female
0305 other medical science
business
Research Article
Zdroj: Journal of the International AIDS Society
ISSN: 1758-2652
Popis: Introduction: Multiple comorbidities among HIV-positive individuals may increase the potential for polypharmacy causing drug-to-drug interactions and older individuals with comorbidities, particularly those with cognitive impairment, may have difficulty in adhering to complex medications. However, the effects of age-associated comorbidities on the treatment outcomes of combination antiretroviral therapy (cART) are not well known. In this study, we investigated the effects of age-associated comorbidities on therapeutic outcomes of cART in HIV-positive adults in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and on cART for more than six months were analysed. Comorbidities included hypertension, diabetes, dyslipidaemia and impaired renal function. Treatment outcomes of patients ≥50 years of age with comorbidities were compared with those
Databáze: OpenAIRE
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