Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews

Autor: Loreto Carmona, Lene Terslev, Michael Doherty, Jenny de la Torre-Aboki, Ingrid Möller Parera, Elena Nikiphorou, Will Uwe Kampen, Raul Castellanos-Moreira, Esperanza Naredo, Maria Antonietta D'Agostino, Francis Berenbaum, Jacqueline Uson, Terence W O'Neill, Sebastian C. Rodriguez-García, Irene A Pitsillidou, Mikael Boesen, Hemant Pandit, V. Vardanyan
Přispěvatelé: Universidad Rey Juan Carlos [Madrid] (URJC), University of Manchester [Manchester], University of Nottingham, UK (UON), Copenhagen University Hospital, Leeds Metropolitan University, Facultat de Medicina [Barcelona], Yerevan State Medical University after Mkhitar Heratsi, Rigshospitalet [Copenhagen], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), King‘s College London, King's College Hospital (KCH), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: RMD Open : Rheumatic & Musculoskeletal Diseases
RMD Open : Rheumatic & Musculoskeletal Diseases, BMJ, 2021, 7 (2), pp.e001658. ⟨10.1136/rmdopen-2021-001658⟩
RMD Open
RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2021, 7 (2), pp.e001658. ⟨10.1136/rmdopen-2021-001658⟩
Rodriguez-García, S C, Castellanos-Moreira, R, Uson, J, Naredo, E, O'Neill, T W, Doherty, M, Boesen, M, Pandit, H, Möller Parera, I, Vardanyan, V, Terslev, L, Kampen, W U, D'Agostino, M A, Berenbaum, F, Nikiphorou, E, Pitsillidou, I, De La Torre-Aboki, J & Carmona, L 2021, ' Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases : An overview of systematic reviews ', RMD Open, vol. 7, no. 2, 001658, pp. 1-20 . https://doi.org/10.1136/rmdopen-2021-001658
RMD Open, Vol 7, Iss 2 (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
ISSN: 2056-5933
Popis: ObjectiveTo summarise the evidence on intra-articular therapies (IAT) to inform the 2020 EULAR recommendations.MethodsAn overview of systematic reviews (SR) including randomised-controlled trials (RCTs) of IAT in adults with arthropathies was performed up to July 2020. Pain, function, and frequency of adverse events were the main efficacy and safety outcomes, respectively. Quality was assessed with the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR)-2 tool.ResultsOf 184 references identified, 16 met the inclusion criteria, and a search of their reference lists identified 16 additional SRs. After quality assessment, 29 were finally included. Of these, 18 focused on knee osteoarthritis (KOA), 6 on hip osteoarthritis (HOA), 3 on shoulder capsulitis (SC), and 3 on rheumatoid arthritis. Overall, hyaluronic acid showed a small effect on pain and function in KOA but not in HOA or shoulder capsulitis. Intra-articular glucocorticoids showed a small effect in pain and function in KOA and function in HOA and SC. Platelet-rich plasma showed benefit in pain and function in KOA but not in HOA. Mesenchymal stem cells behaved similarly. Most SR results were of moderate quality and RCTs included often presented a high risk of bias, mainly due to inadequate blinding and heterogeneous results. All interventions were well tolerated with no clear safety differences.ConclusionsThis overview underlines that most IAT currently used in KOA, HOA, and SC exert small effects and are well tolerated. However, no firm conclusions can be drawn for inflammatory arthritis due to the limited data found.
Databáze: OpenAIRE
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