An aromatase polymorphism (g.132810C>T) predicts risk of bisphosphonate-related osteonecrosis of the jaw
| Autor: | Francesco Crea, Fabio La Ferla, Filippo Graziani, Elisa Paolicchi, Mario Gabriele, Romano Danesi, Silvia Cei |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype medicine.medical_treatment Clinical Biochemistry Estrogen receptor Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Aromatase Risk Factors Internal medicine Drug Discovery medicine Humans Adverse effect Aged Aged 80 and over Diphosphonates biology business.industry Biochemistry (medical) Estrogen Receptor alpha Osteonecrosis Case-control study Middle Aged Bisphosphonate medicine.disease Zoledronic acid Endocrinology Jaw Case-Control Studies biology.protein Female business Osteonecrosis of the jaw Jaw Diseases medicine.drug |
| Zdroj: | Biomarkers in Medicine. 6:201-209 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm.12.14 |
| Popis: | Background: Bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) is an unpredictable, debilitating adverse effect. Recently, genetic polymorphisms have arisen as promising tools to identify patients with a higher risk of drug-related adverse events. Aim: We aimed to examine the association between the aromatase polymorphism g.132810C>T, and the estrogen receptor polymorphisms g.156705T>C and g.156751A>G, and the risk of BP-related ONJ. Methods: Eighty-three subjects were included in the study. A clinical and radiological examination was conducted on oncologic subjects treated with zoledronic acid. Subjects with histologically confirmed ONJ were included in the test group (n = 30) whereas subjects with good oral health were included in control group (n = 53). Aromatase and estrogen receptor polymorphisms from blood samples were analyzed. Results: The aromatase g.132810C>T polymorphism displayed an over-representation of the TT genotype in the test group (36.67 vs 16.98%; p < 0.05). There was no significant difference in either estrogen receptor polymorphism genotype frequency between the test and control groups. Conclusion: Our data suggest a role for the g.132810C>T polymorphism in predicting ONJ risk. These results can pave the way to the personalization of BP therapy, based on individual genotype. |
| Databáze: | OpenAIRE |
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