Interferon (IFN)-gamma-inducible protein-10: Association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection
| Autor: | Romero, AI, Lagging, M, Westin, J, Dhillon, AP, Dustin, LB, Pawlotsky, JM, Neumann, AU (Avidan), Ferrari, C, Missale, G, Haagmans, Bart, Schalm, Solko, Zeuzem, S, Negro, F, Verheij-Hart, E, Hellstrand, K |
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| Přispěvatelé: | Virology, Gastroenterology & Hepatology |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Hepatitis C virus Hepacivirus Biology Interferon alpha-2 medicine.disease_cause Antiviral Agents Virus Polyethylene Glycols chemistry.chemical_compound Interferon-gamma SDG 3 - Good Health and Well-being Interferon Ribavirin medicine Immunology and Allergy Humans Interferon gamma Univariate analysis virus diseases Interferon-alpha Hepatitis C Chronic Middle Aged Viral Load digestive system diseases Recombinant Proteins Chemokine CXCL10 Infectious Diseases Treatment Outcome chemistry Liver Immunology RNA Viral Drug Therapy Combination Female Viral disease Viral load Chemokines CXC medicine.drug |
| Zdroj: | Journal of Infectious Diseases, 194(7), 895-903. Oxford University Press |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/507307 |
| Popis: | BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index |
| Databáze: | OpenAIRE |
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