Responsiveness to bronchodilator procaterol in COPD as assessed by forced oscillation technique
| Autor: | Yoshinori Hasegawa, Akemi Uchida, Satoru Ito, Yoshitaka Isobe |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Vital capacity Physiology Procaterol medicine.drug_class 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Forced Oscillation Technique Bronchodilator Forced Expiratory Volume Oscillometry Tidal Volume Medicine Humans 030212 general & internal medicine Respiratory system Aged Retrospective Studies Aged 80 and over COPD Analysis of Variance Inhalation business.industry General Neuroscience Airway Resistance Impedance Middle Aged medicine.disease Bronchodilator Agents Respiratory Function Tests Airway smooth muscle Airway Forced oscillation technique 030228 respiratory system Spirometry Anesthesia Female business medicine.drug |
| Zdroj: | Respiratory physiologyneurobiology. 240 |
| ISSN: | 1878-1519 |
| Popis: | The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36 Hz before and after inhalation of procaterol, a short-acting β2-agonist (n = 60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation. The Rrs at 4 Hz and Xrs at 4–20 Hz during a whole breath were significantly improved after procaterol inhalation. The response to procaterol inhalation varied among patients, and changes in Xrs at 4 Hz significantly correlated with% change in forced expiratory volume in one second and changes in forced vital capacity. Taken together, Zrs, and specifically Xrs parameters, are sensitive to acute physiological responses to a bronchodilator in COPD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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