Immunomodulation of human macrophages and myeloid cells by 2-substituted (1–3)-β-d-glucan from P. parvulus 2.6
| Autor: | Mateo de las Casas-Engel, Pilar Fernández de Palencia, Paloma López, Angel L. Corbí, Sara Notararigo |
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| Rok vydání: | 2014 |
| Předmět: |
Exopolysaccharides
beta-Glucans Polymers and Plastics 2-substituted (1-3)-β-D-glucan Peripheral blood mononuclear cell Microbiology Immune system Macrophages modulation Lactic acid bacteria Materials Chemistry Humans Immunologic Factors Macrophage Myeloid Cells Pediococcus Cells Cultured biology Macrophages Polysaccharides Bacterial Organic Chemistry Lactococcus lactis Macrophage Activation biology.organism_classification Myeloid cells Cytokines Signal transduction 1 3 β d glucan Signal Transduction |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0144-8617 |
| Popis: | 17 p.-3 fig. glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1–3)- -d-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 proinflammatory monocyte-derived macrophages. The results reveal that this kind of -D-glucan activates macrophages and has an anti-inflammatory effect. This work was supported by the Spanish Ministry of Education grants AGL2009-12998 and AGL2012-40084. |
| Databáze: | OpenAIRE |
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