Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines

Autor:	Patrick J. Middleton, Catherine Lin, Guangyi Wang, Zbigniew Pietrzkowski
Rok vydání:	1999
Předmět:	Clinical Biochemistry Ribonuclease H Oligonucleotides Pharmaceutical Science Biochemistry Receptors Interleukin-8A chemistry.chemical_compound Antigens CD Drug Discovery Humans Molecular Biology Antisense DNA chemistry.chemical_classification Nuclease biology Organic Chemistry RNA hemic and immune systems Receptors Interleukin respiratory system RNase H activity Molecular hybridization Kinetics Enzyme chemistry Models Chemical Duplex (building) biology.protein Molecular Medicine DNA Thymidine
Zdroj:	Bioorganicmedicinal chemistry letters. 9(6)
ISSN:	0960-894X
Popis:	We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61285abe31917518b3583ee339ca7c71 https://pubmed.ncbi.nlm.nih.gov/10206555 Zobrazit plný text záznamu Full Text from ScienceDirect