Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia
| Autor: | Bakhutashvili Vi, I. V. Datunashvili, M. B. Papava, Tamar Sanikidze, N. G. Tkhilava, M. T. Gongadze, D. D. Gamrekelashvili |
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| Rok vydání: | 2006 |
| Předmět: |
Lipopolysaccharides
Male In Vitro Techniques medicine.disease_cause General Biochemistry Genetics and Molecular Biology Nitric oxide Electron Transport Superoxide dismutase Mice chemistry.chemical_compound Oxidoreductase Ribonucleotide Reductases medicine Animals Cytochrome c oxidase Reactive nitrogen species chemistry.chemical_classification Mice Inbred ICR Reactive oxygen species biology Superoxide Dismutase Neuropeptides Electron Spin Resonance Spectroscopy General Medicine Catalase Reactive Nitrogen Species Endotoxemia Oxidative Stress Biochemistry chemistry biology.protein Reactive Oxygen Species Spleen Oxidative stress |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 141:211-215 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-006-0130-3 |
| Popis: | We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected mice from the toxic effect of lipopolysaccharide. |
| Databáze: | OpenAIRE |
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