The cross-reactivity of anti-asparaginase antibodies against different l-asparaginase preparations
| Autor: | Beata Zalewska-Szewczyk, Agnieszka Gach, Jerzy Bodalski, Wojciech Młynarski, Krystyna Wyka |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Asparaginase Enzyme-Linked Immunosorbent Assay Cross Reactions medicine.disease_cause Cross-reactivity Antibodies General Biochemistry Genetics and Molecular Biology L asparaginase chemistry.chemical_compound Internal medicine Escherichia coli medicine Humans chemistry.chemical_classification Hematology biology business.industry Dickeya chrysanthemi General Medicine Enzyme assay Specific antibody Enzyme chemistry Immunology biology.protein Antibody business |
| Zdroj: | Clinical and Experimental Medicine. 9:113-116 |
| ISSN: | 1591-9528 1591-8890 |
| Popis: | Repeated administration of L-asparaginase leads to the development of specific antibodies and hypersensitivity reactions. The aim of the study was to evaluate a possible cross-reaction of anti-asparaginase antibodies, developed against the native E. coli L-asparaginase (Asparaginase Medac), with other preparations of the enzyme. Sixteen patients with acute lymphoblastic leukemia, in whom in the reinduction phase of treatment hypersensitivity against L-asparaginase was observed and/or the presence of anti-asparaginase antibodies was established were recruited for the present study. Ten out of 16 tested sera showed cross-immunoreactivity to PEG-asparaginase, while no reactivity to L-asparaginase derived from Erwinia chrysantemi was observed. Since cross-reacting antibodies were also found in sera of patients with no overt allergic reaction, L: -asparaginase may undergo silent inactivation during the reinduction phase of therapy. This finding is of clinical importance with regard to appropriate dosage and necessitates careful enzyme activity monitoring in all patients undergoing repeated treatment with various L-asparaginase preparations. |
| Databáze: | OpenAIRE |
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