Apolipoprotein B mRNA–Editing Enzyme, Catalytic Polypeptide–Like 3G: A Possible Role in the Resistance to HIV of HIV‐Exposed Seronegative Individuals
| Autor: | Francesco Mazzotta, Alberto Clivio, Francesca Fasano, Yasuyoshi Kanari, Sergio Lo Caputo, Guiliana Magri, Luca Piacentini, Mario Clerici, Daria Trabattoni, Eugenio Cesana, Valentina Naddeo, Mara Biasin, Cristina Bergamaschi, Masaaki Miyazawa, Lucia Lopalco |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Apolipoprotein B
APOBEC-1 Deaminase viruses HIV Infections APOBEC-3G Deaminase Virus Replication Peripheral blood mononuclear cell immune system diseases In vivo Cytidine Deaminase HIV Seropositivity Humans Immunology and Allergy RNA Messenger APOBEC3G biology virus diseases Cytidine deaminase biochemical phenomena metabolism and nutrition biology.organism_classification Virology Infectious Diseases Case-Control Studies Immunology Lentivirus HIV-1 Leukocytes Mononuclear biology.protein Female RNA Editing |
| Zdroj: | The Journal of Infectious Diseases. 195:960-964 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/511988 |
| Popis: | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)--mainly CD14(+) cells--and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|