Prevalence of ocular abnormalities in relation to sickle cell disease severity among children in South-western, Nigeria
| Autor: | Oluwagbemiga O Adeodu, Oluwatoyin H Onakpoya, Samuel Ademola Adegoke, O I Oladimeji |
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| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry 030231 tropical medicine Cell Glaucoma Nigeria General Medicine Disease Anemia Sickle Cell medicine.disease Severity of Illness Index 03 medical and health sciences Ophthalmology 0302 clinical medicine medicine.anatomical_structure Cross-Sectional Studies Disease severity 030221 ophthalmology & optometry Prevalence Medicine Humans Pediatric ophthalmology Sickle cell retinopathy business |
| Zdroj: | European journal of ophthalmology. 31(5) |
| ISSN: | 1724-6016 |
| Popis: | Introduction: Sickle cell disease (SCD) ranks high among genetic disorders worldwide. It is characterised by repeated vaso-occlusion with resultant end-organ damage. This process can occur in all vascular beds in the body, including ocular blood vessels and may cause irreversible blindness in advanced stages. Little is known of the relationship between the prevalence of ocular abnormalities among children with SCD and their disease severity. Methods: A descriptive cross-sectional study was carried out at the Paediatric Haematology Clinics and the Eye Centre of the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife. Children with SCD in steady state were recruited from the Haematology Clinics and examined for ocular abnormalities at the Eye Centre of the hospital. The subjects SCD severity grade was determined using a previously validated scoring system. Results: One hundred and twenty (120) children aged 5 to 15 years were examined. Of these, 72 had one or more ocular abnormalities giving the prevalence of ocular abnormalities among them to be 60.0%. Though a higher proportion of children with moderate disease, 23 (65.7%) of 35, compared to those with mild disease, 49 (57.6%) of 85 had ocular abnormalities, this difference was not statistically significant, p = 0.412. Conclusion: Ocular abnormalities among Nigerian children with SCD are common even in steady-state, but not significantly associated with disease severity. Periodic screening for ocular abnormalities should thus be done on them irrespective of disease severity. |
| Databáze: | OpenAIRE |
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