Survival Impact of Stations of Pathological Lymph Nodes in N2 Non-small Cell Lung Cancer in a French Hospital
| Autor: | Christelle Clément-Duchêne, Stéphanie Lacomme, Olivier Menard, Yves Martinet, Jean-Michel Vignaud, Joëlle Siat, Valentine Anne, Jean-Matthieu Casse, Amandine Luc |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Oncology Lung Neoplasms Kaplan-Meier Estimate 030204 cardiovascular system & hematology 0302 clinical medicine Surgical oncology Carcinoma Non-Small-Cell Lung Aged 80 and over education.field_of_study Mediastinum Middle Aged Prognosis Hospitals Tumor Burden Survival Rate Trachea Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Adenocarcinoma Female France Adult medicine.medical_specialty Population 03 medical and health sciences Sex Factors Internal medicine Tobacco Smoking medicine Carcinoma Humans Neoplasm Invasiveness education Lung cancer Survival rate Aged Proportional Hazards Models Retrospective Studies Proportional hazards model business.industry Retrospective cohort study medicine.disease Blood Vessels Surgery Lymph Nodes business |
| Zdroj: | Annals of Surgical Oncology. 25:1262-1268 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-018-6373-1 |
| Popis: | The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. This study included 342 NSCLC with N2 involvement between 1988 and 2014. Patient-related data were collected through the CRB biobank and included demographic, therapeutic, and survival data. Survival was analyzed according to Kaplan-Maier method. Cox’s regression analysis and analysis of variance (ANOVA) were used to determine factors significantly associated with survival. The population average age was 61.6 years; 82.2% were men, a majority were former smokers (87.1%), and 45.3% had adenocarcinoma. The main prognostic factors were male gender (p = 0.01), number of nodes (p |
| Databáze: | OpenAIRE |
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