Treatment of Idiopathic Membranous Nephropathy
| Autor: | Jerome G. Porush, Jacob Churg, Edith Grishman, Glabman S, Lawrence Garfinkel, Theodore Ehrenreich, Marvin H. Goldstein, Stuart L. Yunis |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Kidney Glomerulus Remission Spontaneous Clinical onset Gastroenterology Basement Membrane Glomerulonephritis Membranous nephropathy Adrenal Cortex Hormones Recurrence Internal medicine medicine Humans In patient Child Aged Retrospective Studies business.industry Follow up studies Infant Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Idiopathic Membranous Nephropathy Surgery Steroid therapy Child Preschool Prednisone Female business Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | New England Journal of Medicine. 295:741-746 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm197609302951401 |
| Popis: | In a retrospective study of the effect of treatment in biopsy-proved idiopathic membranous nephropathy, 91 adults and 12 children were followed for periods up to 29 years after clinical onset (mean, 6.5 years). Forty-four were treated with corticosteroids, 15 with corticosteroids and immunosuppressants; 44 had no treatment and served as a control group. Clinical cure and improvement were significantly greater in the treated than in the nontreated group (P less than 0.01). The recurrence rate, occurrence of renal failure and probability of death were significantly greater in the nontreated group, although some of these patients eventually showed improvement. Prognosis was better in patients who responded to therapy. These data strongly suggest that steroid therapy is beneficial in patients with membranous nephropathy. |
| Databáze: | OpenAIRE |
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